University of Science and Technology of China (USTC) - Division of Molecular Medicine, University of Science and Technology of China (USTC), University of Science and Technology of China (USTC), affiliation not provided to SSRN, affiliation not provided to SSRN, University of Science and Technology of China (USTC), Fudan University, University of Science and Technology of China (USTC) and University of Science and Technology of China (USTC)