affiliation not provided to SSRN, Universidad Autónoma de Madrid - FIIS-Fundacion Jimenez Diaz University Hospital, affiliation not provided to SSRN, Osakidetza Basque Health Service - Basurto University Hospital, Osakidetza Basque Health Service - Basurto University Hospital, Hospital de la Santa Creu i Sant Pau, Hospital de la Santa Creu i Sant Pau, affiliation not provided to SSRN, Hospital Universitario Virgen de la Victoria, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Hospital Universitario de Canarias, Hospital Universitario de Canarias, Hospital Universitario La Paz, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Vall d’Hebron Institute of Oncology (VHIO), affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Hospital Universitari Son Espases, affiliation not provided to SSRN and Universidad Autónoma de Madrid - FIIS-Fundacion Jimenez Diaz University Hospital