affiliation not provided to SSRN, affiliation not provided to SSRN, Hospital Universitario de Canarias, affiliation not provided to SSRN, affiliation not provided to SSRN, Hospital Clínic de Barcelona, Universidad de Barcelona - Hospital Clínic Barcelona, Hospital del Mar, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Instituto de Investigación Biomédica de A Coruña - Complexo Hospitalario Universitario A Coruña, affiliation not provided to SSRN, affiliation not provided to SSRN, Universidad Pública de Navarra - Complejo Hospitalario de Navarra, affiliation not provided to SSRN, Hospital Universitario de Móstoles, Hospital Universitario Virgen de Valme, Hospital General Universitario de Alicante, Hospital de la Santa Creu i Sant Pau, Instituto de Investigación Sanitaria Hospital "12 de Octubre" - Hospital Universitario 12 de Octubre, affiliation not provided to SSRN, affiliation not provided to SSRN, Hospital Marqués de Valdecilla - Internal Medicine Division and Research Institute Marqués de Valdecilla (IDIVAL)