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C Nogueira

Immunocore Ltd

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Improved Production and Quality of Lentiviral Vectors By Major-Splice-Donor Mutation and Co-Expression of a Novel U1 Snrna-Based Enhancer

Number of pages: 63 Posted: 05 Sep 2024
J Wright, B. M. Alberts, A. JM Hood, C Nogueira, Z Miskolczi, C. R. Vieira, D Chipchase, C. M. Lamont, O Goodyear, L. J. Moyce, M Soyombo, D Blount, A. L. Keating, T Coradin, H Huang, Magdalena Martin-Urdiroz, S Ferluga, K. A. Mitrophanous, N. G. Clarkson and D. C. Farley
Oxford BioMedica (UK) Ltd, Oxford BioMedica (UK) Ltd, University of Oxford - Nuffield Department of Medicine, Immunocore Ltd, Adaptimmune Ltd, Independent, Independent, Oxford BioMedica (UK) Ltd, Oxford BioMedica (UK) Ltd, Oxford BioMedica (UK) Ltd, bioMérieux, Barinthus Biotherapeutics plc, University of Oxford - Department of Oncology, iosBio Ltd., Independent, Oxford BioMedica (UK) Ltd, King’s College London, Oxford BioMedica (UK) Ltd, Oxford BioMedica (UK) Ltd and Oxford BioMedica (UK) Ltd
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Gene Therapy, lentiviral vector production, quality and yield, major-splice-donor aberrant splicing, vector RNA genome integrity and packaging, 2KO-LV genome, Transgene Repression in vector Production (TRiP) System[TM], U1 snRNA-based lentiviral vector enhancer, CAR-T cell therapy, TetraVecta[TM] System