Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) - School of Population Medicine and Public Health, Huazhong University of Science and Technology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) - School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) - School of Population Medicine and Public Health, University of Oxford - Rheumatology and Musculoskeletal Sciences, University of Oxford, Peking University - Institute of Child and Adolescent Health, Huazhong University of Science and Technology - Key Laboratory of Environmental Health, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) - School of Population Medicine and Public Health and Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) - State Key Laboratory of Medical Molecular Biology