affiliation not provided to SSRN, Johns Hopkins University, affiliation not provided to SSRN, MedStar Georgetown University Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, Johns Hopkins University, Johns Hopkins University - Department of Surgery, affiliation not provided to SSRN, affiliation not provided to SSRN and Johns Hopkins University - Neuroscience Critical Care Division