Cork University Hospital, affiliation not provided to SSRN, University of Alberta, Mayo Clinic, Mayo Clinic, Johns Hopkins University, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Baylor College of Medicine, University of Washington, Indiana University - School of Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Texas at Houston - MD Anderson Cancer Center, Johns Hopkins University, affiliation not provided to SSRN, affiliation not provided to SSRN, Cornell University - Weill Cornell Medicine, Mayo Clinic and affiliation not provided to SSRN