Keele University - Research Institute for Primary Care and Health Sciences, Keele University - Research Institute for Primary Care and Health Sciences, University of Toronto - Department of Medicine, Keele University - Research Institute for Primary Care and Health Sciences, Keele University - School of Medicine, Keele University - School of Medicine, Children’s National Health System - Department of Cardiology, Jagiellonian University in Krakow, University of Leicester - Leicester Diabetes Centre, The University of Manchester and Keele University - Research Institute for Primary Care and Health Sciences