Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, China Academy of Chinese Medical Sciences - Institute of Chinese Materia Medica, Shenyang Pharmaceutical University and Shenyang Pharmaceutical University - Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development