Federal University of Parana, Federal University of Parana, Federal University of Parana, Federal University of Parana, affiliation not provided to SSRN, Federal University of Parana, Federal University of Parana, affiliation not provided to SSRN, Federal University of Parana, University of São Paulo (USP) - Department of Immunology, affiliation not provided to SSRN, Federal University of Parana, Federal University of Parana, Federal University of Parana, affiliation not provided to SSRN and Federal University of Parana