Tsinghua University, Government of the People's Republic of China - China-Japan Friendship Hospital, Government of the People's Republic of China - Departmet of Pulmonary and Critical Care Medicine, Government of the People's Republic of China - China-Japan Friendship Hospital, Government of the People's Republic of China - China-Japan Friendship Hospital, University of Pittsburgh - Medical Center (UPMC), University of Pittsburgh - Department of Medicine and Pulmonary and Critical Care Medicine, University of Pittsburgh - Department of Medicine and Pulmonary and Critical Care Medicine, University of Pittsburgh - Department of Medicine and Pulmonary and Critical Care Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) - State Key Laboratory of Medical Molecular Biology and Government of the People's Republic of China - Department of Pulmonary and Critical Care Medicine