Hospital Universitari Vall d'Hebron of Barcelona, affiliation not provided to SSRN, University of Duisburg-Essen - University Hospital Essen, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, BG University Hospital Bergmannsheil, Klinikum Oldenburg, University Clinic of Anaesthesiology, Intensive Care, Emergency Medicine, Pain Therapy, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Bambino Gesù Children's Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN and Université Libre de Bruxelles (ULB) - Department of Intensive Care