Keio University, affiliation not provided to SSRN, Keio University, Keio University - Division of Pulmonary Medicine, Keio University, Keio University, Keio University, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University, University of Yamanashi, Keio University, Keio University, Keio University, Keio University, Keio University, University of Yamanashi, Keio University - Center for Medical Genetics, Keio University and Keio University - Division of Pulmonary Medicine