University of Leeds - Institute of Cardiovascular and Metabolic Medicine, University of Leeds, University of British Columbia (UBC) - St. Paul's Hospital, Uppsala University, University of Newcastle - Newcastle University Translational and Clinical Research Institute, University of Newcastle - Newcastle University Translational and Clinical Research Institute, Leeds Teaching Hospitals NHS Trust, University of Leeds, James Cook University Hospital, University of Leeds - Institute of Cardiovascular and Metabolic Medicine, Mount Sinai Health System - Icahn School of Medicine, Liverpool Heart and Chest Hospital, University of Leeds - Leeds Institute for Data Analytics, University of Oxford - Oxford University Hospitals, University of Edinburgh - Centre for Cardiovascular Science, University of Glasgow, University of Leeds - Institute of Cardiovascular and Metabolic Medicine, University College London and University of Leeds - Institute of Cardiovascular and Metabolic Medicine