University of Bristol - Musculoskeletal Research Unit, University of Bristol, University of Bristol, University of Bristol, Biomedical Research and Training Institute, Midlands State University, Midlands State University, Biomedical Research and Training Institute, University of Bristol, University of Oxford, University of Oxford, University of Southampton - Medical Research Council Life Course Epidemiology Unit, University of Oxford and London School of Hygiene & Tropical Medicine - Department of Clinical Research