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Amanda K. Lukens

Massachusetts Institute of Technology and Harvard University - Broad Institute

415 Main Street

Cambridge, MA 02142

United States

  • Massachusetts Institute of Technology and Harvard University - Broad Institute

SCHOLARLY PAPERS

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Scholarly Papers (1)

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Loss of P. falciparum Amino Acid Transporter (ApiAT2) Increases Intracellular Proline and Confers Resistance to Prolyl-tRNA Synthetase Inhibitors

Number of pages: 40 Posted: 03 Mar 2025
Selina Bopp, Lọla Fagbami, Amy Deik, Claudia Taccheri, Akansha Pant, Madeline Luth, Daisy Chen, Mark A. Tye, Imran Ullah, Johannes Kreuzer, Robert Morris, Wilhelm Haas, Elizabeth A. Winzeler, Clary Clish, Amanda K. Lukens, Ralph Mazitschek, Dyann F. Wirth and Sneak Peek Administrator
Harvard University - T.H. Chan School of Public Health, Harvard University - T.H. Chan School of Public Health, Massachusetts Institute of Technology and Harvard University - Broad Institute, Harvard University - T.H. Chan School of Public Health, Harvard University - T.H. Chan School of Public Health, University of California, San Diego (UCSD), University of California, San Diego (UCSD), Harvard University - Massachusetts General Hospital, Harvard University - T.H. Chan School of Public Health, Harvard University - Massachusetts General Hospital, Harvard University - Massachusetts General Hospital, Harvard University - Massachusetts General Hospital, University of California, San Diego (UCSD), Massachusetts Institute of Technology and Harvard University - Broad Institute, Massachusetts Institute of Technology and Harvard University - Broad Institute, Massachusetts General Hospital - Center for Systems Biology, Harvard University - T.H. Chan School of Public Health and Independent
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Abstract:

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Malaria, Plasmodium falciparum, Halofuginone, prolyl tRNA synthetase, Apicomplexan Amino acid Transporter, adaptive proline response, drug resistance