Valais Hospital, affiliation not provided to SSRN, University of Lausanne - Lausanne University Hospital, University of Lausanne, University of Lausanne - Laboratory of Clinical Pharmacology, University of Lausanne, Swiss Institute of Bioinformatics, Swiss Institute of Bioinformatics, University of Lausanne - Lausanne University Hospital, University of Lausanne - Lausanne University Hospital, University of Lausanne - Lausanne University Hospital, Government of the United States of America - National Cancer Institute and University of Geneva - Geneva University Hospitals