affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Washington University - Department of Surgery, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Government of the Commonwealth of Australia - CSIRO (Commonwealth Scientific and Industrial Research Organisation), affiliation not provided to SSRN, University of Melbourne - Florey Institute of Neuroscience and Mental Health, Washington University in St. Louis - Knight Alzheimer Disease Research Center, Washington University in St. Louis - Department of Radiology, Washington University in St. Louis - Knight Alzheimer Disease Research Center, affiliation not provided to SSRN, University of California, San Francisco (UCSF) - Department of Neurology, University of Melbourne - Florey Institute of Neuroscience and Mental Health, Washington University in St. Louis - Department of Radiology, affiliation not provided to SSRN and Washington University Pediatric MS and other Demyelinating Disease Center