The Chinese University of Hong Kong (CUHK) - Department of Medicine & Therapeutics, The Chinese University of Hong Kong (CUHK) - Department of Medicine & Therapeutics, The Chinese University of Hong Kong (CUHK) - Department of Medicine & Therapeutics, affiliation not provided to SSRN, Princess Margaret Hospital, Tai Po Hospital - Department of Medicine & Geriatrics, Pamela Youde Nethersole Eastern Hospital - Department of Medicine, Queen Elizabeth Hospital, Hong Kong - Department of Medicine, Tseung Kwan O Hospital, The Chinese University of Hong Kong (CUHK) - Division of Biostatistics, The Chinese University of Hong Kong (CUHK), The Chinese University of Hong Kong (CUHK), Prince of Wales Hospital, The Chinese University of Hong Kong (CUHK) - Department of Medicine & Therapeutics and The Chinese University of Hong Kong (CUHK) - Department of Medicine & Therapeutics