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Franziska Adermann

affiliation not provided to SSRN

  • affiliation not provided to SSRN

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Solvent-Free Lipid Nanoparticle Formulation Enables In Vivo Gene Editing Predominantly in Extrahepatic Tissues

https://doi.org/10.1002/smll.202511489

Number of pages: 35 Posted: 25 Aug 2025 Last Revised: 31 Mar 2026
Michael Streiber, Na Liu, Laurianne Simon, Franziska Adermann, Vivien Bachmann, Stephanie Hoeppener, Stephanie Schubert, Oliver Werz, Vincent Lapinte, Marie Morille, Michael Bauer, Adrian Press, Ulrich S. Schubert and Anja Traeger
affiliation not provided to SSRN, Jena University - Jena University Hospital, University of Montpellier - Institut Charles Gerhardt Montpellier (ICGM), affiliation not provided to SSRN, affiliation not provided to SSRN, Friedrich-Schiller-Universität Jena, Friedrich-Schiller-Universität Jena - Jena Center for Soft Matter (JCSM), Friedrich-Schiller-Universität Jena - Department of Pharmaceutical/Medicinal Chemistry, University of Montpellier - Institut Charles Gerhardt Montpellier (ICGM), affiliation not provided to SSRN, Jena University - Department of Anesthesiology and Intensive Care Medicine, Jena University, Friedrich-Schiller-Universität Jena - Laboratory of Organic and Macromolecular Chemistry (IOMC) and Friedrich-Schiller-Universität Jena - Laboratory of Organic and Macromolecular Chemistry (IOMC)
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Abstract:

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solvent-free lipid nanoparticles, CRISPR-Cas9, gene delivery, extrahepatic delivery, human primary cells, cholesterol-free