Case Western Reserve University, Case Western Reserve University, affiliation not provided to SSRN, affiliation not provided to SSRN, Case Western Reserve University, Case Western Reserve University, Case Western Reserve University, Case Western Reserve University, Case Western Reserve University, Houston Methodist Research Institute - Houston Methodist Academic Institute, Ruhr University of Bochum - University Hospitals, University of Glasgow - Institute of Cardiovascular and Medical Sciences, Case Western Reserve University and Louis Stokes Cleveland Veterans Administration Medical Center