affiliation not provided to SSRN, National Physical Laboratory, Royal Surrey NHS Foundation Trust, affiliation not provided to SSRN, University College London - University College London Hospitals NHS Foundation Trust, affiliation not provided to SSRN, Swansea Bay University Health Board - Singleton Hospital, Imperial College London - Imperial College Healthcare NHS Trust, University of Dundee - Ninewells Hospital, Royal Surrey NHS Foundation Trust, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Royal Surrey County Hospital, affiliation not provided to SSRN, Royal Surrey NHS Foundation Trust, Belfast Health and Social Care Trust and University College London