Great Ormond Street Hospital for Children NHS Foundation Trust, University of Birmingham, University of Southampton - University Hospital Southampton NHS Foundation Trust, University of Birmingham, University of Birmingham, University of Birmingham, University of Birmingham, Juvenile Arthritis Research, University of Birmingham, Government of the United Kingdom - NIHR Oxford Biomedical Research Centre, University of Oxford - Oxford Vaccine Group, Government of the United Kingdom - NIHR Oxford Biomedical Research Centre, University of Oxford - Centre for Vaccinology and Tropical Medicine, University of Birmingham - Cancer Research UK Clinical Trials Unit, University of Glasgow, University of Glasgow - College of Medical, Veterinary & Life Sciences, University of Birmingham - NIHR Birmingham Biomedical Research Centre and Institute of Cancer and Genomic Sciences and National Institute for Health Research (NIHR)