Southern Medical University, Southern Medical University, Southern Medical University, affiliation not provided to SSRN, Zhuzhou National Engineering Research Center of Converter Technology Co., Ltd, Southern Medical University, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Southern Medical University, Central South University and Southern Medical University - Institute of Antibody Engineering