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Amit Agrey

SporeData Inc

SCHOLARLY PAPERS

76

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Scholarly Papers (76)

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1.

Supervised, Unsupervised, and Reinforcement Learning: A Conceptual Guide for Clinical Researchers

Number of pages: 9 Posted: 14 Nov 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 230 (331,797)

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2.

Markov Models vs. Decision Trees in Health Economics: Which to Use and When

Number of pages: 5 Posted: 12 Nov 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 115 (617,542)

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3.

Synthetic Control Arms in Clinical Trial Design: Leveraging Real-World Data-Advantages, Methodological Considerations, and Pitfalls

Number of pages: 9 Posted: 30 Dec 2025
Lizzy Nkeangnyi, Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 77 (844,901)

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Metabolic Health, Metabolic Disorders

5.

The External Control Arm Method: A Real-World and Synthetic Data Approach for Comparative Effectiveness in Oncology (Motivated by the ECLIPSE Study on Synthetic External Control Arms Using Lung-MAP S1400I)

Number of pages: 20 Posted: 04 Dec 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 58 (980,173)

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6.

Marginal Structural Models: A Causal Framework for Time-Varying Exposure Analysis in Epidemiologic Research (Motivated by the Foundational Work of Robins et al. on Inverse Probability Weighting in HIV Treatment Studies)

Number of pages: 16 Posted: 25 Oct 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 52 (1,041,696)

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7.

Registry-Based Randomized Controlled Trials: An Efficient Framework for Pragmatic Evidence Generation in Cardiovascular Research (Motivated by the TASTE Study on Thrombus Aspiration during ST-Elevation Myocardial Infarction by Fröbert et al.)

Number of pages: 19 Posted: 27 Oct 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 51 (1,052,702)

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8.

When to Use Bayesian vs. Frequentist Methods in Clinical Research: A Practical Decision Framework

Number of pages: 7 Posted: 12 Nov 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 49 (1,074,648)

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Bayesian inference, Frequentist methods, Adaptive clinical trials, Real-world evidence, Cost-effectiveness analysis, Regulatory decision-making, Hybrid statistical frameworks

9.

Integrating Target Trial Emulation and Prospective Trials in Perioperative Research

Number of pages: 22 Posted: 20 Oct 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Antonio Lindenberg, Giselle Zechia, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 47 (1,109,210)

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Target Trial Emulation (TTE), Perioperative Medicine, Observational Data Integration, Learning Health System, Evidence Generation, Pragmatic Clinical Trials, Real-World Evidence, Causal Inference

10.

Improving Trial Site Operations Using Behavioral Science

Number of pages: 106 Posted: 29 Sep 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 47 (1,097,529)

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Behavioral Interventions for Clinical Research, Stakeholder Engagement in Trials, Implementation Frameworks, Behavioral Science in Clinical Trials, Trial Site Operations Optimization, Recruitment and Retention Strategies, Data Quality Improvement

11.

Math Learning in the LLM Era: A Framework for Cognitive Extension in Data Science

Number of pages: 9 Posted: 18 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 46 (1,121,190)

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12.

The Reproducible Research Method: A Cloud-Enabled Approach for Transparent AI Pipelines in Radiology (Motivated by “End-to-End Reproducible AI Pipelines in Radiology Using the Cloud” by Bontempi et al.)

Number of pages: 17 Posted: 03 Dec 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 46 (1,109,210)

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13.

Building Predictive Models of TMS Treatment Response in Chronic Pain

Number of pages: 11 Posted: 17 Nov 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 46 (1,121,190)

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14.

A Very Quick Guide on Choosing the Right Research Approach for Your Data Type in Clinical Research: Qualitative, Quantitative, Mixed-Methods, or Computational

Number of pages: 6 Posted: 12 Nov 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 46 (1,109,210)

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15.

N-of-1 Trials: Personalized Experiments for Real-World Medicine -When and How Clinical Researchers Should Use Them

Number of pages: 7 Posted: 30 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 44 (1,133,231)

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16.

Understanding Model Drift and Why Predictive Models Age in Healthcare: A Guide to the Bewildered

Number of pages: 8 Posted: 30 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 43 (1,157,785)

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17.

Using Large Language Models for Literature Scoping and Gap Identification in Clinical Research

Number of pages: 9 Posted: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 42 (1,157,785)

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18.

Using Large Language Models to Translate Clinical Research for Lay Audiences: A Practical Guide

Number of pages: 9 Posted: 24 Nov 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 42 (1,157,785)

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19.

Propensity Score Overlap Weighting: A Robust Method for Observational Outcome Analysis in Cardiovascular Research (Motivated by the Cleveland Clinic COVID-19 Study on ACEI/ARB Use and SARS-CoV-2 Positivity by Mehta et al.)

Number of pages: 16 Posted: 11 Nov 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 42 (1,157,785)

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20.

Modeling Cortical Excitability in Pain Research: Regression, Mixed-Effects, and Bayesian Approaches

Number of pages: 12 Posted: 17 Nov 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 41 (1,170,409)

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21.

Extended Emotion in Patient-Centered Clinical Research

Number of pages: 7 Posted: 21 Nov 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 40 (1,183,237)

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22.

How LLMs Interpret and Generate Statistical Narratives in Clinical Research

Number of pages: 11 Posted: 20 Nov 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 40 (1,183,237)

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23.

Hybrid Effectiveness-Implementation Designs (Type I-III): A Practical Primer for Clinical Researchers

Number of pages: 8 Posted: 30 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 39 (1,196,171)

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24.

Development of the CRF-TEST Reporting Guideline: Standards for Pre-Trial Testing of Electronic Case Report Forms Using a Delphi Consensus Process For Cancer Trials

Number of pages: 8 Posted: 05 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 39 (1,196,171)

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25.

The Registry-Based Trials Method: A Pragmatic Framework for Comparative-Effectiveness Research in Cardiovascular Care (Motivated by the ADAPTABLE Trial on Aspirin Dosing Strategies by Jones et al.)

Number of pages: 19 Posted: 04 Dec 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 39 (1,196,171)

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26.

Competing Risks Survival Analysis: An Essential Approach for Unbiased Event Prediction in Transplantation Research (Motivated by the BMJ Study on Bias by Censoring for Competing Events by Coemans et al.)

Number of pages: 18 Posted: 21 Nov 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 39 (1,196,171)

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27.

The Hybrid Type 3 Effectiveness–Implementation Trial: A Multicomponent Approach to Advancing Emergency Department–Initiated Buprenorphine for Opioid Use Disorder (Motivated by the Multisite Implementation Facilitation Study by D’Onofrio et al.)

Number of pages: 17 Posted: 25 Oct 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 39 (1,196,171)

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28.

Multiple Imputation: A Principled Strategy for Handling Missing Data in Statistical Analysis (Motivated by the SAS Institute Study on Sensitivity Analysis under MAR and MNAR Assumptions by Yang Yuan)

Number of pages: 16 Posted: 16 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 38 (1,209,354)

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29.

The SHAP Method: A Unified Explainability Technique for Enhancing Transparency in AI-Driven Disease Prediction

Number of pages: 20 Posted: 18 Nov 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 38 (1,222,651)

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30.

Machine Learning Classification: A Robust Approach for ICU Mortality Prediction in Sepsis Patients  (Motivated by the MIMIC-IV Cohort Study on Sepsis Outcomes by Gao et al.)

Number of pages: 12 Posted: 29 Sep 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 38 (1,209,354)

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Machine Learning Classification, Sepsis Mortality Prediction, Intensive Care Unit (ICU), MIMIC-IV Dataset, Clinical Outcome Prediction, Random Forest Model, Model Interpretability (SHAP, Critical Care Decision Support

31.

The RE-AIM Framework: An Evolving Model for Translational Implementation Science (Motivated by Understanding and Applying the RE-AIM Framework: Clarifications and Resources by Holtrop et al.)

Number of pages: 18 Posted: 16 Dec 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 37 (1,222,651)

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32.

The Digital Twins Method: A Mechanistic Modeling Approach for Identifying Ablation Targets in Atrial Fibrillation (Motivated by the Personalized Substrate-Guided Ablation Strategy by Sakata et al.)

Number of pages: 22 Posted: 06 Dec 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 37 (1,222,651)

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33.

The Bias Assessment Method: Evaluating Racial Inequities in Clinical Risk Prediction Models (Motivated by Obermeyer et al.’s Analysis of Cost-Driven Labeling in Healthcare Algorithms)

Number of pages: 16 Posted: 05 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 37 (1,222,651)

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34.

The Propensity Score–Based Method: A Causal Inference Framework for Indirect Comparisons in Single-Arm Oncology Trials (Motivated by Enriching Single-Arm Clinical Trials with External Controls: Possibilities and Pitfalls by Lambert et al.)

Number of pages: 22 Posted: 17 Nov 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 37 (1,222,651)

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35.

Economic Evaluation Frameworks in Clinical Research

Number of pages: 13 Posted: 13 Jan 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 36 (1,249,711)

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36.

The Synthetic Control Arm Method: Advancing Externally Controlled Trial Design Through Improved Real-World Endpoint Measurement (Motivated by Ackerman et al.'s Simulation Study on Bias in Real-World PFS Assessment)

Number of pages: 21 Posted: 04 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 36 (1,236,159)

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37.

Should Funding Agencies Use Value of Information (VOI) Analysis?

Number of pages: 5 Posted: 12 Nov 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 36 (1,236,159)

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38.

Intention-to-Treat vs. Per-Protocol Analyses: When and How -A Guide to the Perplexed

Number of pages: 8 Posted: 07 Jan 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 35 (1,263,436)

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39.

Building Feedback Loops between Human Expertise and Large Language Model Systems in Clinical Research

Number of pages: 8 Posted: 23 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 35 (1,249,711)

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40.

Types of Machine Learning Models by Purpose in Clinical Research -a very Brief Review

Number of pages: 10 Posted: 12 Nov 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 34 (1,263,436)

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41.

Discrete-Event Simulation: A Dynamic Method for Patient State Monitoring in Smart Healthcare Systems (Motivated by the Study on Smart Bed Monitoring for Elderly Patients by Maddeh et al.).

Number of pages: 15 Posted: 09 Oct 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 34 (1,263,436)

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42.

Using LLMs for Peer Review Simulation and Revision Planning in Clinical Research

Number of pages: 8 Posted: 20 Nov 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 33 (1,277,121)

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43.

Bayesian Adaptive Randomization: A Dynamic Method for Efficient Treatment Allocation in Oncology Trials (Motivated by the I-SPY 2 Trial on Neratinib in Early-Stage Breast Cancer by Park et al.)

Number of pages: 14 Posted: 28 Oct 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 33 (1,277,121)

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44.

What Is a Bayesian Adaptive Trial and Why Is It Changing Clinical Research? A Guide to Clinical Researchers

Number of pages: 7 Posted: 07 Jan 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 32 (1,318,317)

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45.

Platform Trials, Basket Trials, Umbrella Trials, and Registry Trials: The Future of Clinical Testing: A Short Tutorial for Clinical Researchers

Number of pages: 9 Posted: 31 Dec 2025 Last Revised: 04 Jan 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 32 (1,290,922)

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Platform Trials, Basket Trials, Umbrella Trials, and Registry Trials: The Future of Clinical

46.

The Delphi Method: A Consensus-Building Approach for Frailty Assessment in Geriatric Research (Motivated by the Korean Frailty and Aging Cohort Study on Operationalizing Frailty Components by Kim et al.)

Number of pages: 17 Posted: 09 Jul 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 32 (1,290,922)

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Aging, Dementia

47.

Scale Development and Factor Analysis: A Rigorous Psychometric Approach for Diabetes Self-Management Assessment (Motivated by the DSMS Validation Study Based on the IMB Model by Dai et al.)

Number of pages: 11 Posted: 09 Jul 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 32 (1,290,922)

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Metabolic Disorders, Metabolic Health

48.

Fixed Versus Adaptive Randomized Trial Designs: Understanding the Tradeoffs – A Practical Guide for Clinical Researchers

Number of pages: 11 Posted: 27 Jan 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 31 (1,318,317)

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49.

Types of Regression Models and When to Use Them: A Really Brief Decision Guide

Number of pages: 7 Posted: 22 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 31 (1,304,549)

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50.

Federated Learning: A Privacy-Preserving Framework for Collaborative Clinical Outcome Prediction in COVID-19 Research (Motivated by the EXAM Study by Dayan et al.)

Number of pages: 15 Posted: 29 Oct 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 30 (1,318,317)

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52.

Survival Analysis: A Crucial Tool for Long-Term Outcome Assessment in Critical Care Research (Motivated by the Retrospective Cohort Study on One-Year ICU Survival by Barisich and Ramírez-Santana)

Number of pages: 12 Posted: 29 Sep 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 30 (1,318,317)

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Survival Analysis, Observational Cohort Studies, High-Dependency Care Units, Long-Term Mortality Prediction, Critical Care Research, Time-to-Event Outcomes

53.

Types of Neural Network Architectures and What they are for: A Primer for Clinical Researchers

Number of pages: 7 Posted: 22 Jan 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 29 (1,372,601)

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54.

The Instrumental Variables Method: A Causal-Inference Framework for Gene Prioritization at Pleiotropic GWAS Loci (Motivated by the Study on Correlated Instrumental Variable Sets by Khan et al.)

Number of pages: 19 Posted: 09 Dec 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 29 (1,332,057)

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55.

The LATCH Algorithm: A Semi-Supervised Approach for Long COVID Phenotyping in Electronic Health Records (Motivated by Hong et al.’s Label-Efficient Framework Integrating Structured and Unstructured EHR Data).

Number of pages: 17 Posted: 01 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 29 (1,332,057)

Abstract:

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56.

Reinforcement Learning: A Data-Driven Framework for Optimizing Sequential Treatment Decisions in Critical Care (Motivated by the AI Clinician Study on Sepsis Management by Komorowski et al.)

Number of pages: 15 Posted: 11 Nov 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 29 (1,332,057)

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57.

Cluster Randomized Controlled Trials: A Rigorous Framework for Evaluating Population-Level HIV Prevention Strategies (Motivated by the HPTN 071 [PopART] Study by Hayes et al.)

Number of pages: 16 Posted: 30 Oct 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 29 (1,332,057)

Abstract:

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58.

Can AI Improve the Fairness of Peer Review? Toward Human-Centered, Reproducible, and Cognitively Augmented Evaluation Systems

Number of pages: 7 Posted: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 28 (1,345,526)

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59.

Progressive Mnemonics Method (PMM) - Progressing from Mnemonics to Understanding in the Mathematical Basis of Data Science Methods Applied to Clinical Research

Number of pages: 8 Posted: 18 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 28 (1,345,526)

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Progressive Mnemonics Method (PMM), Cognitive Load Theory, Dual Memory Systems (Associative and Analytical Memory), Conceptual Understanding in Data Science, Mathematical Learning Framework, Adaptive Learning Environments (AI-Driven Education), Logistic (Sigmoid) Function Example

60.

External Control Arms: A Pragmatic Framework for Comparative Effectiveness Evaluation in Oncology (Motivated by the FDA Review and Case Studies Summarized by Mishra-Kalyani et al.)

Number of pages: 16 Posted: 29 Oct 2025 Last Revised: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 28 (1,345,526)

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61.

Evaluating LLM Literacy and Competence in Clinical Research Teams

Number of pages: 12 Posted: 30 Jan 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 27 (1,359,097)

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62.

The Many Tongues of Meaning: Types of NLP Tasks and When to Use Them -Classification, Extraction, Translation, Summarization

Number of pages: 8 Posted: 09 Jan 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 27 (1,372,601)

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63.

Correlation vs. Association vs. Causation: When Relationships Imply What and Which Analysis Fits -A Primer for Clinical Researchers

Number of pages: 9 Posted: 31 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 27 (1,359,097)

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64.

How Prompt Engineering Actually Works: Structuring Instructions for Language Models -A Practical Guide for Clinical Researchers

Number of pages: 9 Posted: 21 Jan 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 26 (1,385,945)

Abstract:

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65.

Regularization: How Penalties Keep Models Honest A Guide for Clinical Researchers

Number of pages: 9 Posted: 07 Jan 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 26 (1,385,945)

Abstract:

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66.

The Extended Reader in Clinical Data Science: Lifelong Memory and AI-Augmented Interpretation

Number of pages: 7 Posted: 18 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 25 (1,385,945)

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67.

The Data Quality Assessment Method: A Comprehensive Framework for Evaluating Ethnicity Coding Accuracy in Electronic Health Records (Motivated by the OpenSAFELY-TPP Ethnicity Consistency Study by Andrews et al.)

Number of pages: 17 Posted: 05 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 25 (1,385,945)

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Kaplan–Meier Estimation, Population-Based Cohort Studies, Multistate Illness-Death Models, Metabolic Syndrome and Cancer Prognosis, Patient-Centered Survival Analysis, Oncology Outcomes, Remaining Life Expectancy (RLE), Life Years Lost (LYL)

69.

A Reporting Guideline for Clinical Research Methods that are Readable by Humans and Interpretable by Large Language Models

Number of pages: 7 Posted: 28 Jan 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 23 (1,424,331)

Abstract:

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70.

Handling Large Research-Based Texts Using Large Language Models: A Practical Guide

Number of pages: 9 Posted: 18 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 23 (1,411,822)

Abstract:

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71.

Reporting the Use of Large Language Models Across the Research Cycle: A List of Points in Preparation for a Future Guideline

Number of pages: 13 Posted: 19 Dec 2025
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 22 (1,424,331)

Abstract:

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72.

Critique of the PCORI Engagement Rubric: A Framework of Elite Capture

Number of pages: 10 Posted: 01 Apr 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 21 (1,436,435)

Abstract:

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73.

The Registry-to-Bedside Framework for Clinical Model Validation

Number of pages: 9 Posted: 24 Feb 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 21 (1,436,435)

Abstract:

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74.

Bridging Observation and Intervention: A Comparative Framework for DAGs and SWIGs

Number of pages: 13 Posted: 20 Feb 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 20 (1,448,301)

Abstract:

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75.

How Predictive Models of Treatment Response Are Built: Data-to-Decision Pipeline -A Practical Guide for Clinical Researchers

Number of pages: 13 Posted: 30 Jan 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 18 (1,470,786)

Abstract:

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76.

A Comprehensive Methodological Review of Clinical Predictive Model Validation

Number of pages: 18 Posted: 20 Feb 2026
Ricardo Pietrobon, Aline Machiavelli, Luiza Paulsen Rodrigues, Amit Agrey, Lizzy Nkeangnyi, Giselle Zechia, Antonio Lindenberg, Victor Galvão and Lucas Teixeira
SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc, SporeData Inc and SporeData Inc
Downloads 13 (1,518,554)

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