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María Sierra

Hospital Marqués de Valdecilla

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Phospho-Ser235-Rps6 and Il-6 Define a Peripheral Inflammatory Signature in Idiopathic and Lrrk2 G2019s-Associated Parkinson’S Disease: A Functional Validation

Number of pages: 33 Posted: 09 Jul 2025
Almudena Chicote-González, Pol Garcia-Segura, Adriana Cortés, Julia Solana-Balaguer, Genís Campoy-Campos, Alicia Garrido, Jon Infante, Javier Ruiz-Martinez, Manel Fernández, Ramon Díaz, Haizea Hernández-Eguiazu, Ana Vinagre-Aragón, Elisabet Mondragón, Ioana Croitoru, Maria Rivera-Sanchez, Andrea Corrales-Pardo, María Sierra, Eduardo Tolosa, Mario Ezquerra, Rubén Fernández-Santiago, Shalini Padmanabhan, Maria J. Marti, Manuel J. Rodríguez-Allué, Jordi Alberch, Joaquín Fernández-Irigoyen, Enrique Santamaría and Cristina Malagelada
University of Barcelona, University of Barcelona, Universidad Pública de Navarra - Navarrabiomed, University of Barcelona, University of Barcelona, Universidad de Barcelona - Hospital Clínic Barcelona, Hospital Marqués de Valdecilla, University Hospital of Donostia, Hospital Universitario de Navarra, Universidad Pública de Navarra - Navarrabiomed, University Hospital of Donostia, University Hospital of Donostia, University Hospital of Donostia, University Hospital of Donostia, Hospital Marqués de Valdecilla, Hospital Marqués de Valdecilla, Hospital Marqués de Valdecilla, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Universidad de Barcelona - Hospital Clínic Barcelona, Universidad de Barcelona - Hospital Clínic Barcelona, The Michael J. Fox Foundation, Universidad de Barcelona - Hospital Clínic Barcelona, University of Barcelona, University of Barcelona, Universidad Pública de Navarra - Navarrabiomed, University of Navarra - Instituto de Investigación Sanitaria de Navarra (IDISNA) and University of Barcelona
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Abstract:

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Parkinson's disease, peripheral blood mononuclear cells, proteome, phospho-proteome, LRRK2, ribosomal protein S6, Interleukin-6, astrocyte, secretome, phenoconvertion