Prince of Wales Hospital, Hamilton Health Sciences, David Braley Cardiac, Vascular and Stroke Research Institute (DBCVSRI) - Population Health Research Institute, University of Ottawa, David Braley Cardiac, Vascular and Stroke Research Institute (DBCVSRI) - Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute (DBCVSRI) - Population Health Research Institute, McMaster University, Prince of Wales Hospital, McMaster University and McMaster University - Population Health Research Institute