affiliation not provided to SSRN, University of Messina, affiliation not provided to SSRN, affiliation not provided to SSRN, IRCCS Policlinico San Donato, Cork University Hospital, affiliation not provided to SSRN, Erasmus University Rotterdam (EUR) - ThoraxCenter, Lille University, University of Geneva - Geneva University Hospitals, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Abbott Laboratories, affiliation not provided to SSRN, affiliation not provided to SSRN, Lund University, Piedmont Heart Institute, affiliation not provided to SSRN, affiliation not provided to SSRN, Erasmus University Medical Center Rotterdam - Department of Cardiology, Université Laval - Quebec Heart and Lung Institute, Amsterdam UMC, Heart Center, University of Amsterdam, University of Oxford - John Radcliffe Hospital, Harvard University - Beth Israel Deaconess Medical Center, affiliation not provided to SSRN and Duke University - Duke University Hospital