Imperial College London - National Heart and Lung Institute, The University of Manchester, University of Nottingham, University of Dundee, Imperial College London - National Heart and Lung Institute, University of Liverpool, University of Edinburgh, Imperial College London - Imperial NIHR Patient Safety Translational Research Centre, University of the West of England (UWE), University of Edinburgh - Usher Institute, University of Nottingham, University of Oxford - Nuffield Department of Primary Care Health Sciences and Imperial College London - National Heart and Lung Institute