Vancouver General Hospital, BC Cancer - Vancouver, University of Western Ontario - London Health Sciences Centre, Princess Margaret Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Cross Cancer Institute, University of Calgary - Arnie Charbonneau Cancer Institute, McMaster University, Vancouver General Hospital, McMaster University, McGill University, affiliation not provided to SSRN, Saint John of God Hospital, CancerCare Manitoba, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN and affiliation not provided to SSRN