affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Harvard University - Harvard Medical School, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University College London - MRC Clinical Trials Unit, University College London - MRC Clinical Trials Unit, Harvard University - Massachusetts General Hospital, affiliation not provided to SSRN, University of North Carolina (UNC) at Chapel Hill - Department of Medicine, Mercy BioAnalytics, affiliation not provided to SSRN and University College London - MRC Clinical Trials Unit