affiliation not provided to SSRN, Harvard University - Massachusetts General Hospital, Harvard University - Massachusetts General Hospital, Harvard University - Massachusetts General Hospital, affiliation not provided to SSRN, Harvard University - Beth Israel Deaconess Medical Center, affiliation not provided to SSRN, Harvard University - Harvard Medical School, affiliation not provided to SSRN, Harvard University - Beth Israel Deaconess Medical Center, University of Wisconsin-Madison - Department of Neurology, Yale University - School of Medicine, Harvard University - Department of Neurology and Harvard University - Department of Neurology