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Karin Somby

Novartis Institutes for Biomedical Research, Cambridge - Novartis Pharma AG

45 Sidney Street

2nd Floor

Cambridge, MA 02139

United States

  • Novartis Institutes for Biomedical Research, Cambridge - Novartis Pharma AG

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Biopharmaceutics of Subcutaneous Oligonucleotides. Part 1: The Effect of Drug Concentration, Injection Volume and Extracellular Matrix Composition on the Release of Oligonucleotides in Vitro

Number of pages: 17 Posted: 21 Aug 2025
Karin Somby, Clara Mankour, Marieta Duvnjak, Thomas Dimke, Paulo G. Santos, Karoline Bechtold-Peters, Imogen Anastasiou, Conor Gomes, Driton Vllasaliu and Ben Forbes
Novartis Institutes for Biomedical Research, Cambridge - Novartis Pharma AG, Novartis Institutes for Biomedical Research, Cambridge - Novartis Pharma AG, Novartis Institutes for Biomedical Research, Cambridge - Novartis Pharma AG, Novartis Institutes for Biomedical Research, Cambridge - Novartis Pharma AG, Novartis Institutes for Biomedical Research, Cambridge - Novartis Pharma AG, Novartis Pharma AG, Pion Inc, Pion Inc, King’s College London and affiliation not provided to SSRN
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Abstract:

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Subcutaneous injection site simulator (SCISSOR), in vitro release, small interfering ribonucleic acids (siRNA), Antisense Oligonucleotide (ASO), Artificial extracellular matrix (ECM), Collagen, Biopharmaceutics