David Braley Cardiac, Vascular and Stroke Research Institute (DBCVSRI) - Population Health Research Institute, University of Cape Town (UCT), University of Cape Town (UCT) - Division of Cardiology, South African Medical Research Council, McMaster University, Columbia University, McMaster University, McMaster University, McMaster University, World Health Organization (WHO) - Global HIV, Hepatitis and Sexually Transmitted Infections Programmes, University of Cape Town (UCT) - Wellcome Centre for Infectious Diseases Research in Africa, McMaster University - Division of Infectious Diseases, McMaster University - Population Health Research Institute and University of Cape Town (UCT)