affiliation not provided to SSRN, BC Cancer - Vancouver, Princess Margaret Hospital, University of British Columbia (UBC) - Faculty of Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, McMaster University, Cross Cancer Institute, University of Calgary - Arnie Charbonneau Cancer Institute, Vancouver General Hospital, McMaster University, University of Western Ontario - London Health Sciences Centre, McGill University, Saint John of God Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, CancerCare Manitoba, affiliation not provided to SSRN, University of Toronto - University Health Network, affiliation not provided to SSRN and affiliation not provided to SSRN