Universitat Politècnica de Catalunya (UPC Barcelona Tech) - Department of Physics, Fondazione Policlinico Universitario A. Gemelli IRCCS, Institut Català de la Salut - Sistemes d’Informació dels Serveis d’Atenció Primària (SISAP), Carol Davila University of Medicine and Pharmacy, National Institute for Mother and Child Health, Royal Hospital for Children and Young People, University of Bristol - Population Health Sciences, Barnaspitali Hringsins Children's Hospital, Generalitat de Catalunya - Department of Health, Generalitat de Catalunya, Children's Hospital Vall d'Hebron, Children's Hospital Vall d'Hebron, Polytechnic University of Catalonia (UPC) - Computational Biology and Complex Systems (BIOCOM-SC), Leicester University, Autonomous University of Barcelona - Paediatric Infectious Diseases and Immunodeficiencies Unit, University of Edinburgh and Fondazione Policlinico Universitario A. Gemelli IRCCS - Department of Woman and Child Health and Public Health