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Ronnie M. Gravett

University of Alabama at Birmingham

Birmingham, AL 35294-4460

United States

  • University of Alabama at Birmingham

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DNA electroporation of HIV Env elicits unique pattern of immune responses compared to other methods of immunogen delivery, including robust CD8+ responses and memory B cell responses with muted serum antibody levels when boosted with recombinant protein

Number of pages: 32 Posted: 01 Oct 2025
Stephen De Rosa, Ronnie M. Gravett, William O. Hahn, Manuel Villaran, Yunda Huang, Lorel Schmitzberger, David C. Montefiori, Elize Domin, Georgia D. Tomaras, Jack Heptinstall, Kelly E. Seaton, Guido Ferrari, Gabriel Ozorowski, Andrew B. Ward, Wen-Hsin Lee, Lara van der Maas, Laura Polakowski, Ian Frank, Hong-Van Tieu, Spyros A. Kalams, Nina Marie G. Garcia, Jinwei Huang, Sukanya Ghosh, Mansi Purwar, Dan Kulp, Laurent Humeau, Peter Kwong, Juliana McElrath, Lawrence Corey and David B. Weiner
Fred Hutchinson Cancer Research Center - Vaccine and Infectious Disease Division, University of Alabama at Birmingham, affiliation not provided to SSRN, Fred Hutchinson Cancer Research Center, Fred Hutchinson Cancer Research Center - Vaccine and Infectious Disease Division, affiliation not provided to SSRN, Duke University - Duke Human Vaccine Institute, Duke University, Duke University - Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University, Duke University - Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University - Department of Surgery, The Scripps Research Institute - Department of Integrative Structural and Computational Biology, The Scripps Research Institute - Department of Integrative Structural and Computational Biology, The Scripps Research Institute - Department of Integrative Structural and Computational Biology, The Scripps Research Institute, National Institutes of Health, affiliation not provided to SSRN, Columbia University, Vanderbilt University - Division of Infectious Diseases, affiliation not provided to SSRN, Wistar Institute, Wistar Institute, Wistar Institute, Wistar Institute, affiliation not provided to SSRN, Government of the United States of America - Vaccine Research Center, Fred Hutchinson Cancer Research Center - Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center - Vaccine and Infectious Disease Division and University of Pennsylvania - Vaccine Center
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HIV-1 vaccine, DNA vaccine, Clinical Trial, neutralizing antibodies, B cell response, CD8+ T cell response