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Isadora Serraglio Fortes

affiliation not provided to SSRN

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Discovery of a new class based on 6-methoxypyrimidine as efficient low weight reversible inhibitors of SARS-CoV-2 main protease (Mpro) with antiviral activity

Number of pages: 32 Posted: 28 Sep 2025
Isadora Serraglio Fortes, Marcela Silva Lopes, Thais Helena Maciel Fernandes, Cesar Emiliano Hoffmann da Silva, Pedro Fortes Bartolomeu, Giovanna de Jesus Agostinetto, Pavla Fajtová, Raíssa Gasparetto, Martha T. Oliveira, Débora Assumpção Rocha, Fernando R. Spilki, Ana Franco, Fabrício Souza Campos, Rafael Roesler, Anthony J. O’Donoghue and Saulo Fernandes de Andrade
affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, bUniversidade Federal do Rio Grande do Sul, Federal University of ABC (UFABC), affiliation not provided to SSRN, One Health Laboratory, Feevale University, Federal University of Rio Grande do Sul (UFRGS/PPGA), Universidade Federal do Rio Grande do Sul (UFRGS) - Instituto de Ciências Básicas da Saúde, affiliation not provided to SSRN, affiliation not provided to SSRN and affiliation not provided to SSRN
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6-methoxypyrimidine derivatives, reversible inhibitors, SARS-CoV-2 Mpro, antiviral activity, hit optimization, RT-qPCR