affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Florence - Department of Experimental and Clinical Medicine, Wellcome Sanger Institute, affiliation not provided to SSRN, Wellcome Sanger Institute, University of Luxembourg - Department of Life Sciences and Medicine (DLSM), affiliation not provided to SSRN, affiliation not provided to SSRN, University of Florence - Department of Experimental and Clinical Medicine, affiliation not provided to SSRN and University of Florence