affiliation not provided to SSRN, University of Toronto, affiliation not provided to SSRN, University of Toronto - University Health Network, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University Health Network - Tumor Immunotherapy Program, affiliation not provided to SSRN, University of Toronto - University Health Network, University of Toronto, affiliation not provided to SSRN, Vancouver Coastal Health, Vancouver Coastal Health, The Norwegian Radium Hospital Montebello and affiliation not provided to SSRN