Jena University Hospital, Martin Luther University of Halle-Wittenberg, Martin Luther University of Halle-Wittenberg - Institute of General Practice and Family Medicine, Martin Luther University of Halle-Wittenberg - Julius Bernstein-Institute of Physiology, Martin Luther University of Halle-Wittenberg, Martin Luther University of Halle-Wittenberg, Martin Luther University of Halle-Wittenberg - Pediatric Hematology and Oncology, Martin Luther University of Halle-Wittenberg - Institute for Medical Epidemiology, Biometrics and Informatics (IMEBI), Martin Luther University of Halle-Wittenberg, Martin Luther University of Halle-Wittenberg - Institute for Medical Epidemiology, Biometrics and Informatics (IMEBI), University of Bremen, Martin Luther University of Halle-Wittenberg - Institute for Medical Epidemiology, Biometrics and Informatics (IMEBI) and Charite-Universitatsmedizin Berlin