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Naghmeh Khoshgoo

Ontario Institute for Cancer Research

661 University Avenue

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Toronto

Canada

  • Ontario Institute for Cancer Research

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Scholarly Papers (1)

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Proinflammatory Signaling in Ewing Sarcoma Tumor and Myeloid Cells Is Driven by Retroelement Activity and Counteracted by Reverse Transcriptase Inhibitors

Number of pages: 44 Posted: 12 Nov 2025
Valentina Evdokimova, Peter Ruzanov, Hendrik Hassmann, Vincent Hung, Zhenbo Zhang, Andrea Senff-Ribeiro, Naghmeh Khoshgoo, Suky Zheng, Manideep Pachva, Emily Ringwalt, Timothy P. Cripe, Ryan Roberts, Poul Sorensen, Stefan Burdach, Lincoln Stein, Laszlo Radvanyi and Sneak Peek Administrator
Ontario Institute for Cancer Research, Ontario Institute for Cancer Research, Technische Universität München (TUM), Ontario Institute for Cancer Research, Ontario Institute for Cancer Research, Ontario Institute for Cancer Research, Ontario Institute for Cancer Research, Ontario Institute for Cancer Research, University of British Columbia (UBC), Nationwide Children's Hospital - Abigail Wexner Research Institute, Nationwide Children's Hospital, Nationwide Children's Hospital, University of British Columbia (UBC), Technische Universität München (TUM), Ontario Institute for Cancer Research, University of Toronto and Independent
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Abstract:

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Ewing sarcoma, endogenous retroviral elements, HERV-K, LINE-1, extracellular vesicles, cancer-associated inflammation, cGAS, NFkB, STAT3, IFN-I, proinflammatory cytokines