affiliation not provided to SSRN, The University of Sydney - Melanoma Institute Australia, affiliation not provided to SSRN, Netherlands Cancer Institute, University Hospital Zurich, affiliation not provided to SSRN, Fondazione IRCCS Istituto Nazionale dei Tumori, Fondazione IRCCS Istituto Nazionale dei Tumori, Fondazione IRCCS Istituto Nazionale dei Tumori, Queen Elizabeth Hospital, Adelaide, Assistance Publique-Hôpitaux de Paris - Hôpital Saint-Louis, Hôpital Saint-Louis, The University of Western Australia - Fiona Stanley Hospital, University of Tübingen, Universitair Ziekenhuis Brussel, Sir Charles Gairdner Hospital, The University of Sydney - Melanoma Institute Australia, affiliation not provided to SSRN and affiliation not provided to SSRN