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Massimiliano Barolo

affiliation not provided to SSRN

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Beyond Black Box Models: A Systematic Approach to Measure Physics-Based vs. Data-Driven Contributions in Hybrid Process Models

Number of pages: 28 Posted: 22 Nov 2025
Tobias Overgaard, Maria-Ona Bertran, Bo Friis Nielsen, Pierantonio Facco and Massimiliano Barolo
Technical University of Denmark - DTU Compute, affiliation not provided to SSRN, Technical University of Denmark - DTU Compute, affiliation not provided to SSRN and affiliation not provided to SSRN
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Abstract:

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Hybrid modeling, machine learning, Model extrapolation, Knowledge augmentation, Process engineering, Biopharmaceutical processes