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Byung-Hoon Lee

affiliation not provided to SSRN

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Scholarly Papers (1)

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Cytoplasmic TDP-43 aggregation confers a neurotoxic gain-of-function by sequestering mRNA of Thioredoxin 1, thereby suppressing its translation

Number of pages: 55 Posted: 02 Dec 2025
Korea Brain Research Institute, Korea Brain Research Institute, Korea Brain Research Institute, affiliation not provided to SSRN, Korea University, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Department of Brain and Cognitive Sciences, Korea Brain Research Institute, Korea Brain Research Institute, Korea Brain Research Institute, Korea Brain Research Institute, affiliation not provided to SSRN, affiliation not provided to SSRN, Korea University - Department of Chemistry, Kyungpook National University, Korea Brain Research Institute and Korea Brain Research Institute
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Abstract:

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TDP-43 proteinopathy, cytoplasmic aggregation, Thioredoxin 1, Oxidative stress, Mitochondrial dysfunction