affiliation not provided to SSRN, The University of Sydney - NHMRC Clinical Trials Centre, affiliation not provided to SSRN, The University of Western Australia - Fiona Stanley Hospital, affiliation not provided to SSRN, University of Queensland, Border Medical Oncology, Monash Health, affiliation not provided to SSRN, Flinders University, affiliation not provided to SSRN, The University of Sydney - NHMRC Clinical Trials Centre, Macquarie University, The Kinghorn Cancer Centre, Peter MacCallum Cancer Centre, affiliation not provided to SSRN, affiliation not provided to SSRN, The University of Sydney - NHMRC Clinical Trials Centre, Monash University and affiliation not provided to SSRN