affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Centre Hospitalier Universitaire de Toulouse, affiliation not provided to SSRN, Gustave Roussy - Drug Development Department (DITEP), University of Bordeaux - Hôpital Haut-Lévêque, affiliation not provided to SSRN, University of Montpellier - Institut régional du Cancer de Montpellier, Centre Paul Strauss, University of Claude Bernard Lyon 1 - Centre Léon Bérard, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Pisa, University of Perugia, affiliation not provided to SSRN, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Academic Hospital of Udine ASUFC - Department of Oncology, Université de Poitiers - Gastroenterology Department, affiliation not provided to SSRN, affiliation not provided to SSRN, Università Vita-Salute San Raffaele - IRCCS San Raffaele Scientific Institute, Università Vita-Salute San Raffaele - IRCCS Ospedale San Raffaele, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Milano-Bicocca - Fondazione IRCCS San Gerardo dei Tintori, affiliation not provided to SSRN, affiliation not provided to SSRN, Centre Antoine Lacassagne, affiliation not provided to SSRN, University of Lille - CHU Lille, Institut de Cancérologie de l'Ouest - Department of Medical Oncology, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Institut Mutualiste Montsouris, École Normale Supérieure - PSL Research University - Institut Curie, Centre Eugène Marquis - Medical Oncology, Université de Rennes 1 - CHU de Rennes, University of Toulouse - Hospital Rangueil, IRCCS Humanitas Research Hospital, affiliation not provided to SSRN, Centre Hospitalier Universitaire de Toulouse and affiliation not provided to SSRN

Institut Curie, Helora University Hospitals - CHU Helora, University of Lille - CHU Lille and Please see PDF for full list of authors & affiliations

affiliation not provided to SSRN, Gustave Roussy, Université de Poitiers - Gastroenterology Department, University of Besançon - University Hospital Besançon, affiliation not provided to SSRN, CHRU Tours, Université Paris Cité, Bergonié Institute, affiliation not provided to SSRN, Université Paris VI Pierre et Marie Curie - Hôpital Saint-Antoine, affiliation not provided to SSRN, Centre Hospitalier Universitaire de Toulouse, affiliation not provided to SSRN, Assistance Publique-Hôpitaux de Paris - Hôpital Cochin, Assistance Publique-Hopitaux de Paris (AP-HP) - Hôpital Européen Georges Pompidou, Centre Eugène Marquis - Medical Oncology, affiliation not provided to SSRN, Groupe Hospitalier Diaconesses-Croix St-Simon, affiliation not provided to SSRN and University of Lille - CHU Lille