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Yujing He

Shandong First Medical University

Qingdao

China

  • Shandong First Medical University

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ATP-responsive metal–polyphenol networks deliver celastrol to cancer cell mitochondria to activate mtDNA–cGAS–STING axis and boost tumor immunotherapy

Number of pages: 34 Posted: 26 Dec 2025
Zhe Zhang, Jun Tong, Xiang Cao, Wenyue Xu, Zhikang Qi, Xiuru Kuang, Yongzhuo Huang, Yujing He, Congyan Zeng, Mei Hu and Shiyang Shen
affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Shandong First Medical University, affiliation not provided to SSRN, affiliation not provided to SSRN and affiliation not provided to SSRN
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Metal–polyphenol networks, Mitochondrial targeting, ATP-responsive drug release, Mitochondrial DNA, cGAS–STING, Tumor immunotherapy