affiliation not provided to SSRN, Kongju National University, Kongju National University, Gyeongsang National University - Gyeongsang National University Hospital, University of Pennsylvania, Soonchunhyang University, affiliation not provided to SSRN, Korea University of Science and Technology (UST) - Korea Research Institute of Bioscience and Biotechnology (KRIBB), Korea University of Science and Technology (UST) - BioNanotechnology Research Center, Kongju National University and Korea Research Institute of Bioscience and Biotechnology (KRIBB) - BioNanotechnology Research Center