affiliation not provided to SSRN, University of California, San Francisco (UCSF) - Helen Diller Family Comprehensive Cancer Center, affiliation not provided to SSRN, University of California, San Francisco (UCSF), University of Pennsylvania, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of California, San Francisco (UCSF), affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Pennsylvania, University of California, San Francisco (UCSF) - Departments of Otolaryngology-Head and Neck Surgery and of Microbiology and Immunology, University of California, San Francisco (UCSF) and affiliation not provided to SSRN